Idrish Ali

There is a long and strong history of the involvement of inflammatory processes in epilepsy, both as a cause and consequence. Some recent data relating to microglia depletion in newly validated model of self-sustained electrical Status Epilepticus in mice and its impact on the development of temporal lobe epilepsy and related behavioral impairments will be presented. Furthermore, will be discussed the clinically translatable post-traumatic epilepsy model. In that context around 25-30% rats develop epilepsy following a fluid percussion injury. The animals also display chronic behavioral impairments, and these are related to the early neuroinflammatory cascade induced by the brain trauma.