Seizures are more common in children than in adults. In neonates, seizures can lead to epilepsy, while in adults they can lead to cognitive and psychiatric comorbidities. Childhood seizures can impair brain development if they are not effectively controlled with medication. Researchers have been searching for treatments for childhood seizures that are more effective and have fewer side effects than current medications. Cannabinoids, which are found in Cannabis sp, have shown promise in rodents. However, more research is needed to understand how cannabinoids work in the brain and to determine their safety and efficacy in children. We are conducting a study to investigate the effects of acute and chronic treatment with cannabinoids alone or in combination with antiseizure medications (ASM) in the brain of newborn rodents. We are using behavioral and histopathological analysis to assess the effects of cannabinoids on brain development. We are particularly interested in the effects of cannabinoids on neuronal death, hippocampal neurogenesis, gliosis, and inflammation. Our research is essential for understanding the potential of cannabinoids for the treatment of childhood seizures. We are confident that our findings will be valuable to the medical community, and we look forward to discussing them with the basic science and clinical neurology community.