Patrick Forcelli

The basal ganglia have, for over 40 years, been recognized as a choke point in seizure networks. Focal manipulations within basal ganglia targets suppress seizures in a wide range of experimental models. Using a combination of single-unit recording, fiber photometry, optogenetic approaches, and focal pharmacology, this talk will highlight roles for the striatum, substantia nigra, superior colliculus and pedunculopontine nucleus in the control of experimental seizures in rodent and non-human primate models, in an effort to identify therapeutic targets for brain stimulation in the treatment of epilepsy.